SINP: is Licensure (for 2221) is mandatory to obtain before creating EOI profile online?

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I want to apply for SINP under NOC 2221 which comes under - Regulated & Licensed.

I am working as Quality Control Technologist (Microbiologist).

I have done Diploma & Bachelors in MLT & Masters in Industrial Microbiology.

I checked for NOC 2221 - If your education is in a discipline other than agrology, the SIA will not assess your credentials. Provide your educational credential assessment (ECA) from a designated organization.

MY ECA has done from WES and have express entry profile.

MY QUESTION IS:-

Do I need to obtain License before applying to SINP? As mentioned above can my existing ECA will be accepted?

OR Do I need License because my Bachelors & Diploma are in MLT???

PLEASE HELP. I AM TOO CONFUSED.