With your CRS score, pretty low imo
No. Depends on your area of work and your work experience to an extent, but generally very difficult.
You are unlikely to get interviews, let alone an offer if you aren't already a PR, or have exceptional work exp in some in-demand field. If you do somehow get an offer, they'll probably sponsor a closed work permit. Unlikely to happen overall.
- Look for ways to increase your score significantly (490+ at minimum; 500+ if possible)
- Study in Canada and then work there to eventually get a PR
- Gain work exp in an in demand field and hope to get an invite
Nothing more can be done at this point. The days of easy immigration to Canada ended in 2019, and will likely never come back.